not really, same as usual with each iteration of FM, all the changes are little things.
the match engine seems a little better and more fluid (09's 3d ran crappily on my laptop but 10's is fine) but still has some of the same issues it's had for ages (too many long shots/1v1s, defenders sometimes being more than a little silly). the menus have had a bit of a rehaul for the better too.
there are apparently game-breaking problems with not enough decent newgen players being created in the long run, but by the time i get to that stage (it takes me like a couple of weeks to complete a season on average) there will hopefully be a patch or something.
also, customary "lol realism" screenshot.